CPM

Simulated sheet morphology for YAP knockdown (KD) and overexpression (OE) Introduction We model epithelial-mesenchymal transition (EMT) by first assembling an ODE model for intracellular Yes-associated protein (YAP) signalling and then embedding this single cell model within individual cells in a multiscale simulation.

Multiscale simulation of EMT by minimal signaling circuit Introduction We model epithelial-mesenchymal transition (EMT) by first assembling an ODE model for intracellular Yes-associated protein (YAP) signalling and then embedding this single cell model within individual cells in a multiscale simulation.

Introduction Human induced pluripotent stem cells (hiPSCs) can be grown in cell culture where they self-organize spatial patterns. Libby et al. have employed inducible CRISPR interference-driven genetic perturbations to modulate mechanical cell properties like cell-cell adhesion and cortical tension.

Introduction Human induced pluripotent stem cells (hiPSCs) can be grown in cell culture where they self-organize spatial patterns. Libby et al. have employed inducible CRISPR interference-driven genetic perturbations to modulate mechanical cell properties like cell-cell adhesion and cortical tension.

Introduction Human induced pluripotent stem cells (hiPSCs) can be grown in cell culture where they self-organize spatial patterns. Libby et al. have employed inducible CRISPR interference-driven genetic perturbations to modulate mechanical cell properties like cell-cell adhesion and cortical tension.

Introduction The formation and maintenance of three germ layers in colonies of human embryonic stem cells (ESCs) is sensitive to the geometry of the colony. In vitro experiments with micropatterns controlling colony shape have previously addressed the underlying spatio-temporal patterning in Warmflash et al.

Introduction Collective motion of human breast cancer cells of the cell line MDA-MB-231 was studied by Lee et al. for individual crawling cells, cell doublets, cell quadruplets and for confluent populations on a two-dimensional substrate.

Cells' consumption of cytokine concentration Introduction This example serves to demonstrate the implementation of cells consuming a substrate field, e.g. cytokine. Please also see the built-in docu at MorpheuML/Global/Field and Global/System/DiffEqn.

Membrane pattern allows anisotropic release of substance from cell Introduction This example serves to demonstrate a multiscale model of a cell secreting a substance/molecule and propelling away from the secreted substance.

Hybrid continuum-chemical and agent-based cell model Introduction The idea that the diffusion of extracellular signaling molecules sets up non-local cellular communications can also be used to simulate non-local forces using chemoattraction and repulsion.